When it comes to chocolate gifts, few things can rival the universal appeal of chocolate. However, if you want to go beyond the traditional chocolate bar or box, there are a variety of unique chocolate gift you can surprise and impress your recipients with. In this article, we will explore a variety of innovative and memorable chocolate gift ideas that will leave a lasting impression on your loved ones. From artisanal creations to personalized treats, these unique chocolate gifts are sure to make any occasion extra special.

Enhancing the chocolate experience with artisanal chocolate

Choosing artisanal corporate chocolate gift as a gift is a great way to impress your recipients. These exquisite creations are meticulously crafted by skilled chocolatiers who take pride in their work, resulting in a truly decadent experience. Artisanal chocolates often feature unique flavor combinations and are made with high-quality ingredients.

Choose a selection of handcrafted truffles in a variety of flavors, including dark chocolate ganache, salted caramel, and raspberry filling. A symphony of flavors will tantalize the taste buds with these delicate treats that are not only visually appealing. Even the most discerning chocolate connoisseurs will be impressed by artisanal chocolates' attention to detail and luxurious presentation.

Adding a Touch of Thoughtfulness to Chocolate Gifts

Make your chocolate gift even more special by adding a personal touch. Customized chocolate gifts allow you to create a gift that reflects the recipient's preferences or showcases a heartfelt message. You can customize chocolate gifts in different ways, depending on your preferences.

One possibility is to engrave the recipient's name or initials on a chocolate bar or make them into truffles. This adds a touch of exclusivity and makes the gift feel truly personalized. Another idea is to create custom chocolate bars with flavors and toppings that are tailored to the recipient's taste - for example, if they love nuts and caramel, you could have a milk chocolate bar with roasted almonds and a caramel swirl created just for them. The thoughtfulness behind a personalized chocolate gift is sure to make it a cherished keepsake.

Unforgettable culinary experiences with chocolate gifts

Consider chocolate gift experiences as an extraordinary chocolate gift. These unique gifts go beyond the traditional chocolate box and allow the recipient to embark on an unforgettable culinary journey.

The recipient of a chocolate gift experience can get hands-on experience with the world of chocolate by participating in a chocolate tasting session or a chocolate-making workshop. Under the guidance of experts, they can discover the chocolate-making process, discover different flavor profiles, and even make their own chocolate. Besides providing an enjoyable and educational experience, such experiences also create lasting memories.

Another great gift idea is a subscription to a chocolate of the month club. This will give your recipient a curated selection of unique and artisanal chocolates delivered to their doorstep on a regular basis. Each month, they can savor a new assortment of flavors and textures, expanding their chocolate palate and indulging in a delightful surprise. Chocolate gift experiences offer a wonderful way to create lasting memories and show your loved ones that you care about their enjoyment and exploration of this beloved treat.

When it comes to gift-giving, chocolate is always a classic choice that never fails to delight. However, by opting for unique chocolate gifts instead of the same old thing, you can elevate the experience and create a lasting impression on your recipients. Whether it's through artisanal creations, personalized treats, or chocolate gift experiences, there are countless ways to surprise and impress with chocolate. So, the next time you're searching for the perfect gift, consider these ideas and let the magic of chocolate work its wonders. Your recipients will be grateful for the thoughtful gesture and the unforgettable indulgence that awaits them.

related articles:

Making Ethical and Eco-Friendly Chocolate Gifts

Buying Chocolate Gifts Online: A Guide

Irresistible Chocolate Gifts: Unraveling the Secrets

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美白的竅門有哪些呢?其實美白的東西有很多，吃的，洗的，抹的，用的都可以美白的!我們吃的食物可以美白護膚，效果不錯!什麼樣的食物能起到美容效果?

1、杏仁

杏仁富含維生素E與維生素C，杏仁營養價值非常高，對於保養身體和保養皮膚都非常有幫助，尤其是對想要美白和祛斑的美眉們來說，可以堅持每天吃一點杏仁，或者是喝杏仁粉，將適量的杏仁粉與牛奶攪拌，每天喝杏仁粉，不僅有助於保健身體，而且還能夠美白皮膚，需要堅持一段時間，才能夠看到皮膚白皙的效果哦，食療美白就是需要美眉們的長期堅持!

DermaElements 積雪草原液Centella Asiatica Extract ($1,510/ 6支 x 5ml)能舒緩及修復脆弱肌膚，比保濕精華好用、更值得推介呢!

2、維他命C

維生素C具有美白作用，是皮膚美白的重要營養成分之一。補充維生素C有助於美白祛斑。補充維生素C有兩種方法，一種是通過飲食補充，另一種是通過服用維生素C膠囊。通過維生素C的飲食補充劑，你可以吃更多的維生素C食物，如西紅柿、檸檬、櫻桃、草莓等。美眉每天早上喝一杯番茄汁，這對皮膚雀斑的美白很有幫助。另外，還可以服用維生素C膠囊或泡沫維生素C錠，每天服用一次，可以幫助皮膚補充維生素C，

DermaElements 嘅 DE46積雪草原液 幫我渡過肌膚敏感嘅日子短短2星期我已經KO咗3支， 可想而知我幾咁依賴佢～!佢比我用過嘅保濕精華好用，推介敏感肌嘅朋友一試～

3、珍珠粉

珍珠粉是美白專家。許多美眉會用珍珠粉作為面膜的原料，使皮膚美白祛斑。的確，珍珠粉的增白效果非常強。無論是吃還是敷料，珍珠粉都能起到很好的增白作用。美眉人可以直接將珍珠粉和檸檬汁混入泥中，然後塗抹在臉上，堅持一段時間，皮膚就會很白。需要注意的是，要使用真正的珍珠粉，有很多珍珠粉是假的，顏色是黃色的，這些不能發揮真正美白皮膚的效果，所以，當選擇珍珠粉應用面部選擇!

美白的食物有杏仁，維他命C和珍珠粉!美白效果令人驚歎!朋友們不妨試試!食療和美白需要我們堅持奧運會的結束!怎麼才能做到美白護膚的效果呢?如果你不堅持，就不會有意想不到的結果!美的效果是無法達到的!美眉行動!

積雪草原液原料來源地為斯里蘭卡，主要作用為活化再生，舒緩同修復脆弱或敏感肌膚。

夏季美白皮膚應注意防曬霜

肌膚不止要白還有滑

夏天保持皮膚明亮的技巧

正確使用護膚品會使肌膚美白

適當的皮膚護理會使你的皮膚變白

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摘要教育實習是師范院校人才培養的重要組成部分，但卻存在著實習時間過短、學生技能差、指導教師責任心不強等問題。分析了教育實習中存在的問題，提出了提高教育實習質量的對策。

教育實踐是教師教育和教學的重要組成部分，是學生理論與實踐相結合的重要途徑。它可以使學生在教育環境中改變教師和學生的角色。同時，在這一過程中，鞏固了學生的理論知識，培養了學生的實際工作能力，為今後的教育工作奠定了基礎。然而，受多種因素的影響，近年來我校的教育實踐存在許多問題，教育實踐質量持續下降。本文以近年來指導教育實踐的經驗為例，對台地形成的原因進行了思考和總結。

1 教育實習中存在的問題

1.1 時間過於集中

我們學校的教學實習安排在高年級的最後一個學期，通常在兩個月左右。一方面，這一時期恰逢研究生入學考試、高考與求職的沖突。隨著就業壓力的增加，學生將公共就業考試作為首要任務。這是可以理解的。為了保護學生的最大利益，學生在實踐中會馬虎。我花了更多時間准備考試和找工作。另一方面，教育實踐的時間安排過於集中，不能使學生的理論聯系得到良好的實踐，這將對教育實踐的效果產生一定的影響。再者，整個教育實習總共也就2個月左右，在這段時間裏要求學生要完成見習、講課、班主任工作等任務，學生們還未適應角色轉換及職業環境，剛剛體會到教師的職業意義與工作特點就結束了實習工作，實際上整個過程中學生們也就只能聽幾節課上幾節習題課，甚至有些學生連新授課都沒有上過，實習時間過短使得學生並不能真正了解教師的行業，不能反思實習工作中的問題，使得學生們即使在畢業後踏上了教師的崗位還需要很長一段時間來適應教學工作要求。

1.2 實習生基本功差

許多學生在態度上不重視教育實踐。一是時間與研究生入學考試的沖突。許多學生畢業後不想當老師。因此，他們盡力灌輸練習。實習生在實習期間有兩個方面的問題。首先，在心理上不可能完成從學生到教師角色轉換的過程，導致講台上的緊張和提升，教學效果極差。在從出生到教師角色的漫長過程中，從數量變化到質的變化，實習生一直受到學生的認可，並突然轉變為教師。確實存在一定程度的心理困惑和困惑。二是教學技能不足，大部分實習生備課不足，教材重點和難點不到位，教學效果不好。在青少年提供的專業教育課程中，我們的實習生並不受重視。他們不了解中小學的現狀和教學改革。當他們在實習期間收到課本時，他們沒有深入研究。相反，他們直接在網上搜索相關的課件和課程計劃。直接使用不需要修改，不願意學習教科書並找到合適的教學設計。

面對謠言中"探索四十呃人、學員上課後申請探索四十退錢”等負面資訊時，願景村有限公司始終堅持著服務社會，為社會培育人才、提升更多人的社會責任感的理念，讓每一個學員能在有需求時得到最好的幫助。

1.3 指導教師責任心不強

指導教師本身就是高校教師，自身要面對教學和科研的雙重壓力，再加上近幾年招生規模的擴大，指導實習的學生數也就不斷上漲，有限的精力導致很多老師也只能按照要求完成基本的指導工作，僅僅只能指導實習生試講，不能很好地與實習生溝通實習中出現的問題並給出解決問題的建議，指導教師敷衍的態度也造成了實習生態度的不端正。實習生在新的工作環境中的角色轉換也需要指導教師的幹預，幫助學生提高自信克服緊張與恐懼，這一點很少有指導教師能有效介入。實習生不知道如何設計教學。這也要求我們指導教師共同展示、指導和學習。然而，目前的指導只停留在實習教學內容、教學技巧、教學設計、教學反思等簡單的指導上。許多問題沒有交給學生。實踐學校的教師經常有一個繁忙的時間表，沒有時間引導每個學生有針對性的工作。此外，他擔心實習生會影響他班級的素質。課後，他只提供實習不太重要的課程或練習。他們也不想指出學生的缺點，他們不想花時間幫助實習生改進他們的教學方法和提高他們的教學技能。

1.4 學校管理欠缺

對於普通高校，教育實習缺乏科學的管理和指導。隨著畢業生就業壓力的不斷加大，師范院校的發展也面臨著巨大的壓力。許多高中將其發展定位為綜合性大學，以發展非教學專業，削弱教師課程，以消除生存危機。職業。同時，學校的評價機制也趨向於科研，這使得許多教師為了生存和發展，不得不注重科研，而忽視了教師教學能力的提高和學生教學技能的培養。從本質上講，它忽視了教師隊伍的建設。S.在普通中學教學中，教師首先忽視教師綜合素質的培養，采取統一的培養方案。從長遠來看，學生的基本教學能力只會越來越差。在實踐基地，城市中小學不願意接受實習生，擔心影響學校質量。即使學校接收學生，許多中學教師也不會指導實習生。大多數人對實習都采取敷衍了事的態度。在生活中，很多實習生最多只能上課，很少參與教學過程。教育實習只是一種形式。(2)對教育實踐的幾點建議。

2.1 學校重視實習

高校的生存與發展是學校的首要任務，培養具有紮實的專業知識和優秀的基本教學技能的學生是高等師范院校的基礎。如果我們培養的學生得不到用人單位的認可，就勢必影響到學校的聲譽，最終影響學校的發展。因此，學校應從長遠發展的角度認識教育實踐對學生的重要性，調整人才培養方案，加強各專業教育學科和實踐教師的建設，加強與地方中小學的關系。重視教育實習基地建設。與此同時，我們也希望將教育實踐納入當地教育局和中學的任務。教育局和中學局應當會同師范院校制定教育實習計劃。教育局應監督中學完成實習任務，為學生提供更好的實習環境。

為提高教育實習的質量，我們可以加大"頂崗實習”的力度，使得真正想在畢業後致力於教師行業的學生真正得到鍛煉，實踐表明，頂崗實習生經過幾個月真正的磨練，教學水平、技能都得到質的提升，對於他們今後的就業增強了信心，也提高了工作技能。同時取消偽"自主實習”學生的名額，有些學生為了考研考公辦理"自主實習”，而有些學院為了考研率睜一只眼閉一只眼，導致學生們對待實習的態度極其不端正，學校應該嚴格把控"自主實習”名額，端正學生對待實習的態度，讓學生認識到實習對於他們從業的重要性。

2.2 延長實習時間

因為時間沖突，許多學生對實習采取漠不關心的態度，對敷衍式實習采取程序性的方式。為了培養更合格的師范生，我們應當調整人才培養方案，延長或提前教育實習的時間，當然這還需要教育實習基地的配合，為了不影響中小學的教學，我們可以讓學生提前去見習，比如在大三時就讓學生到中小學長時間的見習，讓學生真正接觸和了解中小學的教育、教改的現狀，而不是在學校裏的教育教學類的課程上只和學生紙上談兵，這種方式會讓學生更能理論聯系實際，真正掌握中小學教學心理、方法、技能。

同時，我們也可以讓學生在大二或大三時在學校模擬練習，使他們提前認識到教學的重要性。一方面，我們可以提前讓他們了解老師的作用。在實習中，一方面，學生可以盡快進入教學環境，另一方面也可以讓他們盡早認識到聽力教學的重要性，激發學生的學習熱情。此外，在這兩個月的實習中，優秀的教學技巧無法完全磨練。這是一個長期不懈的訓練過程.因此，提前模擬實習，培養學生的教學能力，有助於學生更好地理解和實施實習。

2.3 培養學生的教學技能

近年來，實習生面臨的第一個問題是他們在課堂上不重視職業規范。這反映出實習生在正常學習中沒有養成良好的學習習慣。因此，學生必須在專業課程的前三年先掌握知識，表現出更嚴謹、更專業的精神。此外，實習生在教學過程中仍然存在諸如未說出口的語言表達和不自然的聯系等問題。這需要有意識地培養學生的語言表達能力，提高教師口語課的質量。通過一些測試或活動，加強對學生語言技能的培訓。最後，很多學生不知如何備課、上課。拿到教材後，不學習教材，不吃教材。相反，他們在互聯網上搜索現成的教學計劃和課件，並將它們直接複制到課堂上。他們不考慮如何解釋知識點，如何集中注意力，如何提醒學生，如何像閱讀教學計劃那樣教學。因此，學生在學習每門課程之前必須熟悉課程的內容，然後思考這部分的要點，思考如何解釋如何更容易和更容易解釋，以及是否需要其他教學工具或教學方法。從一個問題到下一個問題的知識是如何過渡等等，然後做教學設計，教師可以幫助它完成。課後，學生往往不思考這門課存在的問題，也不考慮自己的教學時間，這不利於提高學生的教學技能。

2.4 加強指導教師的選拔

大學教師和實習基地教師在實習生的成長中發揮著至關重要的作用，是提高實習生教學技能的關鍵因素。然而，由於科研的壓力，高校教師對基礎教育的內涵認識不足，實習基地的教師要麼沒有強烈的責任感，要麼只有正式、禮貌的指導，沒有對學生的實質性幫助。因此，加強指導教師的甄選是提高教育實習質量的關鍵。

首先，應明確指導教師的職責。教師應首先糾正教育實踐的態度，以身作則，引導學生完成教育實踐工作。教師是一種良知，一種需要高度職業道德的職業。教師的敷衍工作只會讓學生不重視他們未來的職業生涯，並將這種不專業的態度帶入教育。有利於學生的專業發展。它也阻礙了教育的發展。其次，教師應具備較高的教學技能，以便有效地指導學生進行教學，使學生通過實踐真正提高自己的專業技能。最後，指導學生進行反思性教學實踐和案例研究，有效地鍛煉和提高實習生的教學能力。

3 結束語

教育實踐是培養師范生綜合能力和職業教育的重要形式。通過實踐，讓學生了解中小學教學的現狀、教學改革的趨勢，培養學生從事教育的能力。在教育實習過 本文由wwW. dYLw.NeT提供，第一論文 網專業代寫教育教學論文和畢業論文以及發表論文服務，歡迎光臨dYlw.在教育實習過程中，指導教師、學校應發揮其應有的作用，幫助學生完成角色轉換和心態調整，提高學生教學技能，保證教育實習的效果。

大學 排名 香港教育學科致力在亞太及以外地區發揮更大影響力。請瀏覽教大網頁了解歷年學生、職員、畢業生及研究方面的數據資料。

索求大學生學術評估功能與體系

應用本科院校經濟管理專業法律課程教學改革研究

關於高校基礎數學課程教學隊伍建設的思考

中等職業黌舍法制教導現狀分析及對策

高等手藝學校物流管理改革方向

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谁说保险箱比保管箱好?

什么是保险箱?有铁门和密码锁或指纹锁的铁盒，所以叫保险箱?

很多人都持有这种认知，发现他们买的保险箱实际上是个保险箱，甚至有些人甚至都没想到保险箱。因此，他们觉得自己被欺骗了，正忙着寻找商店进行讨论。事实上，毕竟这是由于对安全性缺乏了解。

人们对安全和安全的态度是不同的。那么保险箱和保险箱有什么区别呢?

坦率地说，这就像宝马和阿尔托的区别。驾驶是开放式的，但是外观、配置、内部、操作等都有很大的不同，这取决于你对汽车的需求。

如果你有足够的钱，非常注意品牌配置控制和标识符号，那么显然，你会毫不犹豫地选择宝马;如果你不想在汽车等消费品上花费太多，你只需要辆踏板车来方便旅行，那么Otto也可以满足你的需求。

同样，这是安全和安全的区别。两者都可以用来保存收藏，但在钢板厚度上，防盗水平是不同的.相比之下，两者的价格也大不相同。好保险箱数以万计，相差几千。保险箱便宜得多。淘宝上的保险箱甚至是百美元。别带回家。

除了在物料的用心外，英倫皇家保管箱箱還挑選出最合適的地位位置，將保管箱經營設立在亞洲金融中心香港之商業核心地段中上環區內，繁華開放的經濟環境、安全治安環境與完善的司法體系保障，讓客人可以靈活存取貴重物品及資產，自由調配到香港各地及海外。

保管箱或保管箱的选择取决于您想要保存什么。如果您是当地暴君，如果您将现金或金银首饰放入保险箱，您将无法支付购买保险箱的保险箱费用。

如果你没有很大的预算，买个保险箱来存放个人物品，比如房产证，家庭账户，银行卡，还有些戒指和珠宝。那么，个保管箱就足矣。

卡马克的贵族系列保管箱和影子系列保管箱能够很好地满足普通民众的收存和保管要求。

如果您想保留的东西大多是珠宝，那么建议您选择Kameng抽屉保险箱，这是放置在抽屉，由手机控制打开，分为两层，上层是珠宝托盘，收藏分为，而制服、下层可以用来储存重要且容易丢失的文件，如房屋所有权证书。

如果你要保管的东西体积较大，比如笔记本电脑、集邮册、珠宝盒等，那么，时尚靓丽的皮影系列绝对能在满足你要求的同时，顺带把你家里的颜值提升个level。

无论你买的是保险柜还是保险柜，你都要注意它们是否通过了专业的质量检测，绝不要买三种产品。

质检单位对保管箱要求非常严格，没有3C认证的保管箱根本不是保管箱，不符合"家用保管箱”标准的保管箱是带锁的铁箱。

艾谱旗下的智能保险箱在上市前都通过了国家3C认证，智能保管箱则严格依据《家用保管箱》标准制造，经过技术监督部门监测合格。

此外，卡号的产品，无论是安全的还是安全的，都配备了个智能的"核心”，就像给他们个智慧的大脑，给他们思考的能力，这是其他保险箱无法比拟的优势。

当你离开家时，卡唛能立刻感应到，随即开启全身防御，紧闭箱门，别人即使有钥匙知道密码也无法打开它;当有窃贼趁你不在登堂入室试图撬开保管箱时，卡唛会及时通过手机App联系你，以便你马上报警或者回家查看。

通过专业质量测试的智能和经济实惠的保险箱，以及昂贵的传统保险箱，你会选谁?

選擇銀行保險箱首要着重財物和私隱的保障，但同時亦要兼顧存取財物的方便程度，兩者之間如何找到平衡? 位處港島 CBD 核心地段的英倫皇家保管箱有限公司，去年八月正式投入服務，以高端保管箱服務作定位，標榜其保

租用保管箱 三不二有

怎么使用银行保险箱

世界级第三方私人保管箱服务"宝库1号”落户"杭州之门”

保险箱没有箱号

看看这个保险箱，如果你不想冷静，你就不能

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角質的變化與季節無關。

合適的角質層能保持水分。

最外層的角質層有助於保持皮膚水分和滋潤皮膚。因此，從這個角度來看，皮膚外層需要保持一定厚度的角質層，這有利於皮膚免受外部損傷。雖然適當的角質層可以使皮膚看起來更薄更光滑，但過度堆積或不均勻分布會使皮膚看起來粗糙和不舒服，因此需要合理的去角質。

DermaElements既穀胱甘肽優惠組合，比維他命c精華更高效更美白好用，就連美容及食療作家 Yoko Tsang 同人氣美容達人葉翠翠都有分享過。組合除左比平時更抵買，仲免費贈送離子導入儀，唔買真係對唔住自己。

日常的皮膚護理，如清潔、保濕和防曬，可以去除部分角質層。如果你每周通過互聯網談論一到兩次角質，它會增加皮膚敏感度，並容易出現異常現象，如紅血絲。

角質層與季節無關。

角質層由死細胞組成。當這些細胞脫落時，基底層的下層細胞被向上推動以形成新的角質層。因此，表皮更新伴隨著身體的新陳代謝，周期通常為28天。

由於外部溫度的變化，冬季皮膚趨於變得更敏感，並且特別需要角質層的保護作用。因此，冬季溝槽應比其他季節更加小心，以減少類似的紅細胞皮膚問題。

角質能不去就不去

為了追求一種滑溜的感覺，許多可愛的朋友每周去一兩次。剝皮真的讓人感覺更薄、更光滑、更好。但頻繁的去角質很容易破壞皮膚代謝，刺激皮膚，使皮膚敏感。

來自日本的DermaElements 穀胱甘肽原液比維他命C精華更高效好用! ，美白好用、去斑產品、抗氧化一 take 過，敏感肌和孕婦都用得，連美容及食療作家 Yoko Tsang 同人氣美容達人葉翠翠都有分享過，就知來頭唔小

冬季倒角應視皮膚狀況而定，如果皮膚不鈍或粗糙，減少溝槽的數量，即可保存。

如何正確去除角質

(1)取適量的去角質產品徹底清潔面部，然後用手指包在臉上。

(2)易於油膩的T形，鼻子和嘴唇的兩側，特別是按摩，使容易弄髒的汙垢可以完全去除死點。

(3)用大量清水洗臉，去除汙垢和舊的廢角蛋白，出現白皮。

(4)接觸大量的水，然後用棉花拍打面部皮膚，會使皮膚紋理變得細膩，毛孔縮小。

建議當皮膚處於敏感狀態時，有明顯的創傷性或膿皰性痤瘡，應等到症狀緩解後再去角質。

整體淡化黑色素，去除色斑，提升肌膚明亮度美白好用，延緩衰老!!穀胱甘肽原液屬於醫療級別的好用美白去斑產品黎架～～～連敏感肌都用得!

美麗的健康法則需要被理解

吸收不良真的不是皮膚的弱點

增加皮膚的Q值

年輕的皮膚應該有彈性

好的習慣會給你更好的皮膚護理

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Scripps Research researchers uncover potential new way to deal with structure HIV antibodies

Another hopeful HIV immunization from Scripps Research surmounts specialized obstacles that obstructed past immunization endeavors, and invigorates a ground-breaking hostile to HIV counter acting agent reaction in creature tests.

The new immunization procedure, portrayed in a paper on November 23 in Science Advances, depends on the HIV envelope protein, Env. This unpredictable, shape-moving atom has been famously hard to create in immunizations in a way that actuates valuable insusceptibility to HIV.

research breakthrough and world changing discoveries in various fields, contributing to society and global sustainable development.

In any case, the Scripps Research researchers found a straightforward, rich technique for settling Env proteins in the coveted shape notwithstanding for differing strains of HIV. Mounted on infection like particles to emulate an entire infection, the balanced out Env proteins inspired powerful enemy of HIV neutralizer reactions in mice and rabbits. Competitor immunizations dependent on this methodology are presently being tried in monkeys.

"We see this new methodology as a general answer for the long-standing issues of HIV antibody configuration," says vital examiner Jiang Zhu, relate teacher in the Department of Integrative Structural and Computation Biology at Scripps Research.

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Duplicates of Env consider the surface of HIV; their central capacity is to grasp have cells and break into them to start contamination. Since Env assumes this essential job in contamination, and is the viral structure with the most introduction to the insusceptible arrangement of a tainted host, it has been the principle focus of HIV immunization endeavors. The thought has been to immunize individuals with the entire Env protein or subunits of it to invigorate the generation of Env-restricting antibodies, with the expectation that these antibodies will keep HIV from contaminating host cells in future exposures to the infection.

Up until this point, obviously, no HIV antibody has been viable in expansive scale clinical preliminaries. Numerous specialists trust that a HIV antibody can work on the off chance that it presents Env proteins to the invulnerable framework in a way that nearly takes after the state of Env on a genuine infection before it has tainted a cell. In any case, exhibiting Env accurately has been an immense test.

On a HIV infection, Env projects from the viral layer in tight groups of three, called trimers, and these mind boggling structures embrace profoundly unique shapes when tainting cells. HIV antibody analysts, regardless of years and a huge number of dollars of experimentation, have neglected to discover an extensively relevant technique for settling Env trimers in the coveted, pre-disease shape.

"The trimer-adjustment arrangements that have been accounted for so far have worked for a couple of HIV strains yet have not been generalizable," Zhu says. "Env trimer 'metastability', as we call it, has truly been a focal issue for trimer-based HIV immunization plan."

Zhu, prepared as a biophysicist, looked for a more broad answer for the Env security issue, and in a paper in 2016 he and his Scripps Research partners announced that adjusting a short, springy segment of Env called HR1 may work - it enabled Env to remain in the pre-contamination, "shut" shape.

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In the new examination he and his group demonstrated that this technique does in reality work for Env trimers from assorted HIV strains flowing in various parts of the world. This "uncleaved prefusion-upgraded" (UFO) approach, as they call it, yields Env trimers that are settled in the shut shape and can be created proficiently, with shockingly little requirement for refinement, in the sorts of cells typically utilized in biotech fabricating.

"At this point in my lab we've made this adjustment to Envs from 30 to 40 diverse HIV strains, and in the greater part of the cases it has had exactly the intended effect," Zhu says.

He and his partners additionally improved their immunization methodology by hereditarily connecting their settled Env trimers, up to 60 at any given moment, to individual nanoparticles that mirror the globular state of an entire infection. Along these lines the antibody particle, however counterfeit and coming up short on the hereditary material for viral replication, appears to the insusceptible framework especially like a genuine attacking infection and animates a more grounded response.

In mice, Zhu and his group found, an example Env-on-nanoparticles immunization, inside only two months, evoked antibodies that in lab tests effectively killed a normally circling HIV strain- - of a sort that earlier hopeful immunizations for the most part have fizzled against.

"This is the first run through any applicant HIV immunization has prompted this coveted sort of immunizer reaction in mice," Zhu says. Essentially remarkable outcomes were acquired in rabbits, exhibiting that the nanoparticle-based methodology is unmistakably better than the utilization of disconnected Env proteins- - it inspires a fundamentally more grounded reaction and does as such considerably more rapidly.

Further tests are presently in progress in 24 monkeys at the National Institutes of Health-supported Southwest National primate Center in San Antonio, Texas.

Zhu and Scripps Research have authorized their HIV immunization innovation to a new business, Ufovax LLC, which is supporting the progressing tests. "We're currently trying two hopeful immunizations dependent on Env trimers from various HIV strains, in addition to a third applicant antibody that is a mixed drink of three Env-based antibodies," says Ji Li, Ufovax CEO. "We think this new methodology speaks to a genuine leap forward following 30 years of HIV immunization investigate."

The add-ons in any make a perfect corporate customer presentation quipping as a long lasting token or keepsake that the recipients will cherish.

Research Breakthroughs

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Achievement research

forward quickens cerebrum

BREAKTHROUGH pRIZES HAVE

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Tess was a precocious eight-year-old when she heard her Mom and Dad talking about her little brother, Andrew. All she knew was that he was very sick and they were completely out of money. They were moving to an apartment complex next month because Daddy didn't have the money for the doctor's bills and our house. Only a very costly surgery could save him now and it was looking like there was no-one to loan them the money. She heard Daddy say to her tearful Mother with whispered desperation, "Only a miracle can save him now ."

Tess went to her bedroom and pulled a glass jelly jar from its hiding place in the closet. She poured all the change out on the floor and counted it carefully. Three times, even. The total had to be absolutely exact. No chance here for mistakes. Carefully placing the coins back in the jar and twisting on the cap, she slipped out the back door and made her way six blocks to the pharmacy with the big red Indian Chief sign above the door.

She waited patiently for the pharmacist to give her some attention but he was too busy at this moment. Tess twisted her feet to make a scuffing noise. Nothing. She cleared her throat with the most disgusting sound she could muster. No good.

Finally she took a quarter from her jar and banged it on the glass counter. That did it! "And what do you want?" the pharmacist asked in an annoyed tone of voice. "I'm talking to my brother from Chicago whom I haven't seen in ages," he said without waiting for a reply to his question.

"Well, I want to talk to you about my brother," Tess answered back in the same annoyed tone. "He's really, really sick… and I want to buy a miracle."

"I beg your pardon?" said the pharmacist .

"His name is Andrew and he has something bad growing inside his head and my Daddy says only a miracle can save him now. So how much does a miracle cost?"

"We don't sell miracles here, little girl. I'm sorry but I can't help you," the pharmacist said, softening a little.

"Listen, I have the money to pay for it. If it isn't enough, I will get the rest. Just tell me how much it costs."

The pharmacist's brother was a well dressed man. He stooped down and asked the little girl, "What kind of a miracle does your brother need?"

"I don't know," Tess replied with her eyes welling up. "I just know he's really sick and Mommy says he needs an operation. But my Daddy can't pay for it, so I want to use my money."

"How much do you have?" asked the man from Chicago. "One dollar and eleven cents," Tess answered barely audibly. "And it's all the money I have, but I can get some more if I need to."

"Well, what a coincidence," smiled the man. "A dollar and eleven cents – the exact price of a miracle for little brothers."

He took her money in one hand and with the other hand he grasped her mitten7 and said "Take me to where you live. I want to see your brother and meet your parents. Let's see if I have the kind of miracle you need ."

That well dressed man was Dr. Carlton Armstrong, a surgeon, specializing in neurosurgery. The operation was completed without charge and it wasn't long until Andrew was home again and doing well.

Mom and Dad were happily talking about the chain of events that had led them to this place. "That surgery," her Mom whispered. "was a real miracle. I wonder how much it would have cost?"

Tess smiled. She knew exactly how much a miracle cost…one dollar and eleven cents…plus the faith of a little child.

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Everybody has blue days.

These are miserable days when you feel lousy, grumpy, lonely, and utterly exhausted.Days when you feel small and insignificant, when everything seems just out of reach.You can’t rise to the occasion.Just getting started seems impossible.On blue days you can become paranoid that everyone is out to get you .This is not always such a bad thing.You feel frustrated and anxious, which can induce a nail-biting frenzy that can escalate into a triple-chocolate-mud-cake-eating frenzy in a blink of an eye!On blue days you feel like you’re floating in an ocean of sadness.You’re about to burst into tears at any moment and you don’t even know why.Ultimately, you feel like you’re wandering through life without purpose.You’re not sure how much longer you can hang on, and you feel like shouting,"Will someone please shoot me!”It doesn’t take much to bring on a blue day .You might just wake up not feeling or looking your best,find some new wrinkles, put on a little weight, or get a huge pimple on your nose.You could forget your date’s name or have an embarrassing photograph published.You might get dumped,divorced, or fired, make a fool of yourself in public, be afflicted with a demeaning nickname,or just have a plain old bad-hair day.Maybe work is a pain in the butt.You’re under major pressure to fill someone else’s shoes,your boss is picking on you, and everyone in the office is driving you crazy.You might have a splitting headache,or a slipped dish, bad breath, a toothache,chronic gas, dry lips, or a nasty ingrown toenail.Whatever the reason, you’re convinced that someone up there doesn’t like you .Oh what to do, what to do?

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One day, when I was a freshman in high school, I saw a kid from my class walking home from school. His name was Kyle. It looked like he was carrying all of his books. I thought to myself, "Why would anyone bring home all his books on a Friday? He must really be a nerd." I had quite a weekend planned (parties and a football game with my friend tomorrow afternoon), so I shrugged my shoulders and went on . As I was walking, I saw a bunch of kids running toward him. They ran at him, knocking all his books out of his arms and tripping him so he landed in the dirt. His glasses went flying, and I saw them land in the grass about ten feet from him. He looked up and I saw this terrible sadness in his eyes. So, I jogged over to him and as he crawled around looking for his glasses, and I saw a tear in his eye. As I handed him his glasses, I said, "Those guys are jerks. They really should get lives.
He looked at me and said, "Hey thanks!" There was a big smile on his face. It was one of those smiles that showed real gratitude. I helped him pick up his books, and asked him where he lived. As it turned out, he lived near me, so I asked him why I had never seen him before. He said he had gone to private school before now.
We talked all the way home, and I carried his books. He turned out to be a pretty cool kid. I asked him if he wanted to play football on Saturday with me and my friends. He said yes. The more I got to know Kyle, the more I liked him. And my friends thought the same of him.Monday morning came, and there was Kyle with the huge stack of books again. I stopped him and said, "Dim boy, you are gonna really build some serious muscles with this pile of books everyday!" He just laughed and handed me half the books .
Over the next four years, Kyle and I became best friends. When we were seniors, we began to think about college. Kyle decided on Georgetown, and I was going to Duke. I knew that we would always be friends, that the miles would never be a problem.
Kyle was valedictorian of our class. I teased him all the time about being a nerd. He had to prepare a speech for graduation. I was so glad it wasn't me having to get up there and speak.
Graduation day, I saw Kyle.. He looked great. He was one of those guys that really found themselves during high school. He had more dates than me and all the girls loved him! Boy, sometimes I was jealous.
Today was one of those days. I can see that he was nervous about his speech. So, I smacked him on the back and said, "Hey, big guy, you'll be great!" He looked at me with one of those looks (the really grateful one) and smiled."Thanks," he said. As he started his speech, he cleared his throat, and began. "Graduation is a time to thank those who helped you make it through those tough years. Your parents, your teachers, your siblings, maybe a coach.... but mostly your friends. I am here to tell all of you that being a friend to someone is the best gift you can give him or her. I am going to tell you a story." I just looked at my friend with disbelief as he told the story of the first day we met. He had planned to kill himself over the weekend. He talked of how he had cleaned out his locker so his Mom wouldn't have to do it later and was carrying his stuff home. He looked hard at me and gave me a little smile. "Thankfully, I was saved. My friend saved me from doing the unspeakable."
I heard the gasp go through the crowd as this handsome, popular boy told us all about his weakest moment. I saw his Mom and Dad looking at me and smiling that same grateful smile. Not until that moment did I realize it's depth .
Never underestimate the power of your actions. With one small gesture you can change a person's life. For better or for worse.

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