June 30, 2023
When it comes to chocolate gifts, few things can rival the universal appeal of chocolate. However, if you want to go beyond the traditional chocolate bar or box, there are a variety of unique chocolate gift you can surprise and impress your recipients with. In this article, we will explore a variety of innovative and memorable chocolate gift ideas that will leave a lasting impression on your loved ones. From artisanal creations to personalized treats, these unique chocolate gifts are sure to make any occasion extra special.
Enhancing the chocolate experience with artisanal chocolate
Choosing artisanal corporate chocolate gift as a gift is a great way to impress your recipients. These exquisite creations are meticulously crafted by skilled chocolatiers who take pride in their work, resulting in a truly decadent experience. Artisanal chocolates often feature unique flavor combinations and are made with high-quality ingredients.
Choose a selection of handcrafted truffles in a variety of flavors, including dark chocolate ganache, salted caramel, and raspberry filling. A symphony of flavors will tantalize the taste buds with these delicate treats that are not only visually appealing. Even the most discerning chocolate connoisseurs will be impressed by artisanal chocolates' attention to detail and luxurious presentation.
Adding a Touch of Thoughtfulness to Chocolate Gifts
Make your chocolate gift even more special by adding a personal touch. Customized chocolate gifts allow you to create a gift that reflects the recipient's preferences or showcases a heartfelt message. You can customize chocolate gifts in different ways, depending on your preferences.
One possibility is to engrave the recipient's name or initials on a chocolate bar or make them into truffles. This adds a touch of exclusivity and makes the gift feel truly personalized. Another idea is to create custom chocolate bars with flavors and toppings that are tailored to the recipient's taste - for example, if they love nuts and caramel, you could have a milk chocolate bar with roasted almonds and a caramel swirl created just for them. The thoughtfulness behind a personalized chocolate gift is sure to make it a cherished keepsake.
Unforgettable culinary experiences with chocolate gifts
Consider chocolate gift experiences as an extraordinary chocolate gift. These unique gifts go beyond the traditional chocolate box and allow the recipient to embark on an unforgettable culinary journey.
The recipient of a chocolate gift experience can get hands-on experience with the world of chocolate by participating in a chocolate tasting session or a chocolate-making workshop. Under the guidance of experts, they can discover the chocolate-making process, discover different flavor profiles, and even make their own chocolate. Besides providing an enjoyable and educational experience, such experiences also create lasting memories.
Another great gift idea is a subscription to a chocolate of the month club. This will give your recipient a curated selection of unique and artisanal chocolates delivered to their doorstep on a regular basis. Each month, they can savor a new assortment of flavors and textures, expanding their chocolate palate and indulging in a delightful surprise. Chocolate gift experiences offer a wonderful way to create lasting memories and show your loved ones that you care about their enjoyment and exploration of this beloved treat.
When it comes to gift-giving, chocolate is always a classic choice that never fails to delight. However, by opting for unique chocolate gifts instead of the same old thing, you can elevate the experience and create a lasting impression on your recipients. Whether it's through artisanal creations, personalized treats, or chocolate gift experiences, there are countless ways to surprise and impress with chocolate. So, the next time you're searching for the perfect gift, consider these ideas and let the magic of chocolate work its wonders. Your recipients will be grateful for the thoughtful gesture and the unforgettable indulgence that awaits them.
related articles:
Making Ethical and Eco-Friendly Chocolate Gifts
Buying Chocolate Gifts Online: A Guide
Irresistible Chocolate Gifts: Unraveling the Secrets
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June 28, 2019
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May 24, 2019
摘è¦æ•™è‚²å¯¦ç¿’æ˜¯å¸«èŒƒé™¢æ ¡äººæ‰åŸ¹é¤Šçš„é‡è¦çµ„æˆéƒ¨åˆ†ï¼Œä½†å»å˜åœ¨è‘—實習時間éŽçŸã€å¸ç”ŸæŠ€èƒ½å·®ã€æŒ‡å°Žæ•™å¸«è²¬ä»»å¿ƒä¸å¼·ç‰å•é¡Œã€‚分æžäº†æ•™è‚²å¯¦ç¿’ä¸å˜åœ¨çš„å•é¡Œï¼Œæ出了æ高教育實習質é‡çš„å°ç–。
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1 教育實習ä¸å˜åœ¨çš„å•é¡Œ
1.1 時間éŽæ–¼é›†ä¸
我們å¸æ ¡çš„æ•™å¸å¯¦ç¿’安排在高年級的最後一個å¸æœŸï¼Œé€šå¸¸åœ¨å…©å€‹æœˆå·¦å³ã€‚一方é¢ï¼Œé€™ä¸€æ™‚期æ°é€¢ç ”究生入å¸è€ƒè©¦ã€é«˜è€ƒèˆ‡æ±‚è·çš„æ²–çªã€‚隨著就æ¥å£“åŠ›çš„å¢žåŠ ï¼Œå¸ç”Ÿå°‡å…¬å…±å°±æ¥è€ƒè©¦ä½œç‚ºé¦–è¦ä»»å‹™ã€‚這是å¯ä»¥ç†è§£çš„。為了ä¿è·å¸ç”Ÿçš„最大利益,å¸ç”Ÿåœ¨å¯¦è¸ä¸æœƒé¦¬è™Žã€‚我花了更多時間准備考試和找工作。å¦ä¸€æ–¹é¢ï¼Œæ•™è‚²å¯¦è¸çš„時間安排éŽæ–¼é›†ä¸ï¼Œä¸èƒ½ä½¿å¸ç”Ÿçš„ç†è«–è¯ç³»å¾—到良好的實è¸ï¼Œé€™å°‡å°æ•™è‚²å¯¦è¸çš„效果產生一定的影響。å†è€…,整個教育實習總共也就2個月左å³ï¼Œåœ¨é€™æ®µæ™‚é–“è£è¦æ±‚å¸ç”Ÿè¦å®Œæˆè¦‹ç¿’ã€è¬›èª²ã€ç主任工作ç‰ä»»å‹™ï¼Œå¸ç”Ÿå€‘還未é©æ‡‰è§’色轉æ›åŠè·æ¥ç’°å¢ƒï¼Œå‰›å‰›é«”會到教師的è·æ¥æ„義與工作特點就çµæŸäº†å¯¦ç¿’工作,實際上整個éŽç¨‹ä¸å¸ç”Ÿå€‘也就åªèƒ½è½å¹¾ç¯€èª²ä¸Šå¹¾ç¯€ç¿’題課,甚至有些å¸ç”Ÿé€£æ–°æŽˆèª²éƒ½æ²’有上éŽï¼Œå¯¦ç¿’時間éŽçŸä½¿å¾—å¸ç”Ÿä¸¦ä¸èƒ½çœŸæ£äº†è§£æ•™å¸«çš„è¡Œæ¥ï¼Œä¸èƒ½åæ€å¯¦ç¿’工作ä¸çš„å•é¡Œï¼Œä½¿å¾—å¸ç”Ÿå€‘å³ä½¿åœ¨ç•¢æ¥å¾Œè¸ä¸Šäº†æ•™å¸«çš„å´—ä½é‚„需è¦å¾ˆé•·ä¸€æ®µæ™‚間來é©æ‡‰æ•™å¸å·¥ä½œè¦æ±‚。
1.2 實習生基本功差
許多å¸ç”Ÿåœ¨æ…‹åº¦ä¸Šä¸é‡è¦–教育實è¸ã€‚ä¸€æ˜¯æ™‚é–“èˆ‡ç ”ç©¶ç”Ÿå…¥å¸è€ƒè©¦çš„æ²–çªã€‚許多å¸ç”Ÿç•¢æ¥å¾Œä¸æƒ³ç•¶è€å¸«ã€‚å› æ¤ï¼Œä»–們盡力çŒè¼¸ç·´ç¿’。實習生在實習期間有兩個方é¢çš„å•é¡Œã€‚首先,在心ç†ä¸Šä¸å¯èƒ½å®Œæˆå¾žå¸ç”Ÿåˆ°æ•™å¸«è§’色轉æ›çš„éŽç¨‹ï¼Œå°Žè‡´è¬›å°ä¸Šçš„緊張和æå‡ï¼Œæ•™å¸æ•ˆæžœæ¥µå·®ã€‚在從出生到教師角色的漫長éŽç¨‹ä¸ï¼Œå¾žæ•¸é‡è®ŠåŒ–到質的變化,實習生一直å—到å¸ç”Ÿçš„èªå¯ï¼Œä¸¦çªç„¶è½‰è®Šç‚ºæ•™å¸«ã€‚確實å˜åœ¨ä¸€å®šç¨‹åº¦çš„心ç†å›°æƒ‘和困惑。二是教å¸æŠ€èƒ½ä¸è¶³ï¼Œå¤§éƒ¨åˆ†å¯¦ç¿’生備課ä¸è¶³ï¼Œæ•™æé‡é»žå’Œé›£é»žä¸åˆ°ä½ï¼Œæ•™å¸æ•ˆæžœä¸å¥½ã€‚在é’å°‘å¹´æ供的專æ¥æ•™è‚²èª²ç¨‹ä¸ï¼Œæˆ‘們的實習生並ä¸å—é‡è¦–。他們ä¸äº†è§£ä¸å°å¸çš„ç¾ç‹€å’Œæ•™å¸æ”¹é©ã€‚ç•¶ä»–å€‘åœ¨å¯¦ç¿’æœŸé–“æ”¶åˆ°èª²æœ¬æ™‚ï¼Œä»–å€‘æ²’æœ‰æ·±å…¥ç ”ç©¶ã€‚ç›¸å,他們直接在網上æœç´¢ç›¸é—œçš„課件和課程計劃。直接使用ä¸éœ€è¦ä¿®æ”¹ï¼Œä¸é¡˜æ„å¸ç¿’教科書並找到åˆé©çš„æ•™å¸è¨è¨ˆã€‚
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1.3 指導教師責任心ä¸å¼·
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1.4 å¸æ ¡ç®¡ç†æ¬ 缺
å°æ–¼æ™®é€šé«˜æ ¡ï¼Œæ•™è‚²å¯¦ç¿’缺ä¹ç§‘å¸çš„管ç†å’ŒæŒ‡å°Žã€‚隨著畢æ¥ç”Ÿå°±æ¥å£“力的ä¸æ–·åŠ å¤§ï¼Œå¸«èŒƒé™¢æ ¡çš„ç™¼å±•ä¹Ÿé¢è‡¨è‘—巨大的壓力。許多高ä¸å°‡å…¶ç™¼å±•å®šä½ç‚ºç¶œåˆæ€§å¤§å¸ï¼Œä»¥ç™¼å±•éžæ•™å¸å°ˆæ¥ï¼Œå‰Šå¼±æ•™å¸«èª²ç¨‹ï¼Œä»¥æ¶ˆé™¤ç”Ÿå˜å±æ©Ÿã€‚è·æ¥ã€‚åŒæ™‚,å¸æ ¡çš„評價機制也趨å‘æ–¼ç§‘ç ”ï¼Œé€™ä½¿å¾—è¨±å¤šæ•™å¸«ç‚ºäº†ç”Ÿå˜å’Œç™¼å±•ï¼Œä¸å¾—ä¸æ³¨é‡ç§‘ç ”ï¼Œè€Œå¿½è¦–äº†æ•™å¸«æ•™å¸èƒ½åŠ›çš„æ高和å¸ç”Ÿæ•™å¸æŠ€èƒ½çš„培養。從本質上講,它忽視了教師隊ä¼çš„建è¨ã€‚S.在普通ä¸å¸æ•™å¸ä¸ï¼Œæ•™å¸«é¦–先忽視教師綜åˆç´ 質的培養,采å–統一的培養方案。從長é 來看,å¸ç”Ÿçš„基本教å¸èƒ½åŠ›åªæœƒè¶Šä¾†è¶Šå·®ã€‚在實è¸åŸºåœ°ï¼ŒåŸŽå¸‚ä¸å°å¸ä¸é¡˜æ„接å—實習生,擔心影響å¸æ ¡è³ªé‡ã€‚å³ä½¿å¸æ ¡æŽ¥æ”¶å¸ç”Ÿï¼Œè¨±å¤šä¸å¸æ•™å¸«ä¹Ÿä¸æœƒæŒ‡å°Žå¯¦ç¿’生。大多數人å°å¯¦ç¿’都采å–æ•·è¡äº†äº‹çš„態度。在生活ä¸ï¼Œå¾ˆå¤šå¯¦ç¿’生最多åªèƒ½ä¸Šèª²ï¼Œå¾ˆå°‘åƒèˆ‡æ•™å¸éŽç¨‹ã€‚教育實習åªæ˜¯ä¸€ç¨®å½¢å¼ã€‚(2)å°æ•™è‚²å¯¦è¸çš„幾點建è°ã€‚
2.1 å¸æ ¡é‡è¦–實習
é«˜æ ¡çš„ç”Ÿå˜èˆ‡ç™¼å±•æ˜¯å¸æ ¡çš„首è¦ä»»å‹™ï¼ŒåŸ¹é¤Šå…·æœ‰ç´®å¯¦çš„å°ˆæ¥çŸ¥è˜å’Œå„ªç§€çš„基本教å¸æŠ€èƒ½çš„å¸ç”Ÿæ˜¯é«˜ç‰å¸«èŒƒé™¢æ ¡çš„基礎。如果我們培養的å¸ç”Ÿå¾—ä¸åˆ°ç”¨äººå–®ä½çš„èªå¯ï¼Œå°±å‹¢å¿…影響到å¸æ ¡çš„è²è½ï¼Œæœ€çµ‚影響å¸æ ¡çš„ç™¼å±•ã€‚å› æ¤ï¼Œå¸æ ¡æ‡‰å¾žé•·é 發展的角度èªè˜æ•™è‚²å¯¦è¸å°å¸ç”Ÿçš„é‡è¦æ€§ï¼Œèª¿æ•´äººæ‰åŸ¹é¤Šæ–¹æ¡ˆï¼ŒåŠ å¼·å„å°ˆæ¥æ•™è‚²å¸ç§‘和實è¸æ•™å¸«çš„建è¨ï¼ŒåŠ 強與地方ä¸å°å¸çš„關系。é‡è¦–教育實習基地建è¨ã€‚與æ¤åŒæ™‚,我們也希望將教育實è¸ç´å…¥ç•¶åœ°æ•™è‚²å±€å’Œä¸å¸çš„任務。教育局和ä¸å¸å±€æ‡‰ç•¶æœƒåŒå¸«èŒƒé™¢æ ¡åˆ¶å®šæ•™è‚²å¯¦ç¿’計劃。教育局應監ç£ä¸å¸å®Œæˆå¯¦ç¿’任務,為å¸ç”Ÿæ供更好的實習環境。
為æ高教育實習的質é‡ï¼Œæˆ‘們å¯ä»¥åŠ 大"é ‚å´—å¯¦ç¿’â€çš„力度,使得真æ£æƒ³åœ¨ç•¢æ¥å¾Œè‡´åŠ›æ–¼æ•™å¸«è¡Œæ¥çš„å¸ç”ŸçœŸæ£å¾—到é›ç…‰ï¼Œå¯¦è¸è¡¨æ˜Žï¼Œé ‚崗實習生經éŽå¹¾å€‹æœˆçœŸæ£çš„磨練,教å¸æ°´å¹³ã€æŠ€èƒ½éƒ½å¾—到質的æå‡ï¼Œå°æ–¼ä»–們今後的就æ¥å¢žå¼·äº†ä¿¡å¿ƒï¼Œä¹Ÿæ高了工作技能。åŒæ™‚å–消å½"自主實習â€å¸ç”Ÿçš„åé¡ï¼Œæœ‰äº›å¸ç”Ÿç‚ºäº†è€ƒç ”考公辦ç†"自主實習â€ï¼Œè€Œæœ‰äº›å¸é™¢ç‚ºäº†è€ƒç ”率çœä¸€åªçœ¼é–‰ä¸€åªçœ¼ï¼Œå°Žè‡´å¸ç”Ÿå€‘å°å¾…實習的態度極其ä¸ç«¯æ£ï¼Œå¸æ ¡æ‡‰è©²åš´æ ¼æŠŠæŽ§"自主實習â€åé¡ï¼Œç«¯æ£å¸ç”Ÿå°å¾…實習的態度,讓å¸ç”Ÿèªè˜åˆ°å¯¦ç¿’å°æ–¼ä»–們從æ¥çš„é‡è¦æ€§ã€‚
2.2 延長實習時間
å› ç‚ºæ™‚é–“æ²–çªï¼Œè¨±å¤šå¸ç”Ÿå°å¯¦ç¿’采å–æ¼ ä¸é—œå¿ƒçš„態度,å°æ•·è¡å¼å¯¦ç¿’采å–程åºæ€§çš„æ–¹å¼ã€‚為了培養更åˆæ ¼çš„師范生,我們應當調整人æ‰åŸ¹é¤Šæ–¹æ¡ˆï¼Œå»¶é•·æˆ–æå‰æ•™è‚²å¯¦ç¿’的時間,當然這還需è¦æ•™è‚²å¯¦ç¿’基地的é…åˆï¼Œç‚ºäº†ä¸å½±éŸ¿ä¸å°å¸çš„æ•™å¸ï¼Œæˆ‘們å¯ä»¥è®“å¸ç”Ÿæå‰åŽ»è¦‹ç¿’,比如在大三時就讓å¸ç”Ÿåˆ°ä¸å°å¸é•·æ™‚間的見習,讓å¸ç”ŸçœŸæ£æŽ¥è§¸å’Œäº†è§£ä¸å°å¸çš„教育ã€æ•™æ”¹çš„ç¾ç‹€ï¼Œè€Œä¸æ˜¯åœ¨å¸æ ¡è£çš„教育教å¸é¡žçš„課程上åªå’Œå¸ç”Ÿç´™ä¸Šè«‡å…µï¼Œé€™ç¨®æ–¹å¼æœƒè®“å¸ç”Ÿæ›´èƒ½ç†è«–è¯ç³»å¯¦éš›ï¼ŒçœŸæ£æŽŒæ¡ä¸å°å¸æ•™å¸å¿ƒç†ã€æ–¹æ³•ã€æŠ€èƒ½ã€‚
åŒæ™‚,我們也å¯ä»¥è®“å¸ç”Ÿåœ¨å¤§äºŒæˆ–大三時在å¸æ ¡æ¨¡æ“¬ç·´ç¿’,使他們æå‰èªè˜åˆ°æ•™å¸çš„é‡è¦æ€§ã€‚一方é¢ï¼Œæˆ‘們å¯ä»¥æå‰è®“他們了解è€å¸«çš„作用。在實習ä¸ï¼Œä¸€æ–¹é¢ï¼Œå¸ç”Ÿå¯ä»¥ç›¡å¿«é€²å…¥æ•™å¸ç’°å¢ƒï¼Œå¦ä¸€æ–¹é¢ä¹Ÿå¯ä»¥è®“他們盡早èªè˜åˆ°è½åŠ›æ•™å¸çš„é‡è¦æ€§ï¼Œæ¿€ç™¼å¸ç”Ÿçš„å¸ç¿’熱情。æ¤å¤–,在這兩個月的實習ä¸ï¼Œå„ªç§€çš„æ•™å¸æŠ€å·§ç„¡æ³•å®Œå…¨ç£¨ç·´ã€‚這是一個長期ä¸æ‡ˆçš„訓練éŽç¨‹.å› æ¤ï¼Œæå‰æ¨¡æ“¬å¯¦ç¿’,培養å¸ç”Ÿçš„æ•™å¸èƒ½åŠ›ï¼Œæœ‰åŠ©æ–¼å¸ç”Ÿæ›´å¥½åœ°ç†è§£å’Œå¯¦æ–½å¯¦ç¿’。
2.3 培養å¸ç”Ÿçš„æ•™å¸æŠ€èƒ½
近年來,實習生é¢è‡¨çš„第一個å•é¡Œæ˜¯ä»–å€‘åœ¨èª²å ‚ä¸Šä¸é‡è¦–è·æ¥è¦èŒƒã€‚這åæ˜ å‡ºå¯¦ç¿’ç”Ÿåœ¨æ£å¸¸å¸ç¿’ä¸æ²’有養æˆè‰¯å¥½çš„å¸ç¿’ç¿’æ…£ã€‚å› æ¤ï¼Œå¸ç”Ÿå¿…é ˆåœ¨å°ˆæ¥èª²ç¨‹çš„å‰ä¸‰å¹´å…ˆæŽŒæ¡çŸ¥è˜ï¼Œè¡¨ç¾å‡ºæ›´åš´è¬¹ã€æ›´å°ˆæ¥çš„精神。æ¤å¤–,實習生在教å¸éŽç¨‹ä¸ä»ç„¶å˜åœ¨è«¸å¦‚未說出å£çš„語言表é”å’Œä¸è‡ªç„¶çš„è¯ç³»ç‰å•é¡Œã€‚這需è¦æœ‰æ„è˜åœ°åŸ¹é¤Šå¸ç”Ÿçš„語言表é”能力,æ高教師å£èªžèª²çš„質é‡ã€‚通éŽä¸€äº›æ¸¬è©¦æˆ–æ´»å‹•ï¼ŒåŠ å¼·å°å¸ç”Ÿèªžè¨€æŠ€èƒ½çš„培訓。最後,很多å¸ç”Ÿä¸çŸ¥å¦‚何備課ã€ä¸Šèª²ã€‚拿到教æ後,ä¸å¸ç¿’æ•™æ,ä¸åƒæ•™æ。相å,他們在互è¯ç¶²ä¸Šæœç´¢ç¾æˆçš„æ•™å¸è¨ˆåŠƒå’Œèª²ä»¶ï¼Œä¸¦å°‡å®ƒå€‘ç›´æŽ¥è¤‡åˆ¶åˆ°èª²å ‚ä¸Šã€‚ä»–å€‘ä¸è€ƒæ…®å¦‚何解釋知è˜é»žï¼Œå¦‚何集ä¸æ³¨æ„力,如何æ醒å¸ç”Ÿï¼Œå¦‚何åƒé–±è®€æ•™å¸è¨ˆåŠƒé‚£æ¨£æ•™å¸ã€‚å› æ¤ï¼Œå¸ç”Ÿåœ¨å¸ç¿’æ¯é–€èª²ç¨‹ä¹‹å‰å¿…é ˆç†Ÿæ‚‰èª²ç¨‹çš„å…§å®¹ï¼Œç„¶å¾Œæ€è€ƒé€™éƒ¨åˆ†çš„è¦é»žï¼Œæ€è€ƒå¦‚何解釋如何更容易和更容易解釋,以åŠæ˜¯å¦éœ€è¦å…¶ä»–æ•™å¸å·¥å…·æˆ–æ•™å¸æ–¹æ³•ã€‚從一個å•é¡Œåˆ°ä¸‹ä¸€å€‹å•é¡Œçš„知è˜æ˜¯å¦‚何éŽæ¸¡ç‰ç‰ï¼Œç„¶å¾Œåšæ•™å¸è¨è¨ˆï¼Œæ•™å¸«å¯ä»¥å¹«åŠ©å®ƒå®Œæˆã€‚課後,å¸ç”Ÿå¾€å¾€ä¸æ€è€ƒé€™é–€èª²å˜åœ¨çš„å•é¡Œï¼Œä¹Ÿä¸è€ƒæ…®è‡ªå·±çš„æ•™å¸æ™‚間,這ä¸åˆ©æ–¼æ高å¸ç”Ÿçš„æ•™å¸æŠ€èƒ½ã€‚
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May 02, 2019
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February 21, 2019
角質的變化與å£ç¯€ç„¡é—œã€‚
åˆé©çš„角質層能ä¿æŒæ°´åˆ†ã€‚
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November 27, 2018
Scripps Research researchers uncover potential new way to deal with structure HIV antibodies
Another hopeful HIV immunization from Scripps Research surmounts specialized obstacles that obstructed past immunization endeavors, and invigorates a ground-breaking hostile to HIV counter acting agent reaction in creature tests.
The new immunization procedure, portrayed in a paper on November 23 in Science Advances, depends on the HIV envelope protein, Env. This unpredictable, shape-moving atom has been famously hard to create in immunizations in a way that actuates valuable insusceptibility to HIV.
research breakthrough and world changing discoveries in various fields, contributing to society and global sustainable development.
In any case, the Scripps Research researchers found a straightforward, rich technique for settling Env proteins in the coveted shape notwithstanding for differing strains of HIV. Mounted on infection like particles to emulate an entire infection, the balanced out Env proteins inspired powerful enemy of HIV neutralizer reactions in mice and rabbits. Competitor immunizations dependent on this methodology are presently being tried in monkeys.
"We see this new methodology as a general answer for the long-standing issues of HIV antibody configuration," says vital examiner Jiang Zhu, relate teacher in the Department of Integrative Structural and Computation Biology at Scripps Research.
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Duplicates of Env consider the surface of HIV; their central capacity is to grasp have cells and break into them to start contamination. Since Env assumes this essential job in contamination, and is the viral structure with the most introduction to the insusceptible arrangement of a tainted host, it has been the principle focus of HIV immunization endeavors. The thought has been to immunize individuals with the entire Env protein or subunits of it to invigorate the generation of Env-restricting antibodies, with the expectation that these antibodies will keep HIV from contaminating host cells in future exposures to the infection.
Up until this point, obviously, no HIV antibody has been viable in expansive scale clinical preliminaries. Numerous specialists trust that a HIV antibody can work on the off chance that it presents Env proteins to the invulnerable framework in a way that nearly takes after the state of Env on a genuine infection before it has tainted a cell. In any case, exhibiting Env accurately has been an immense test.
On a HIV infection, Env projects from the viral layer in tight groups of three, called trimers, and these mind boggling structures embrace profoundly unique shapes when tainting cells. HIV antibody analysts, regardless of years and a huge number of dollars of experimentation, have neglected to discover an extensively relevant technique for settling Env trimers in the coveted, pre-disease shape.
"The trimer-adjustment arrangements that have been accounted for so far have worked for a couple of HIV strains yet have not been generalizable," Zhu says. "Env trimer 'metastability', as we call it, has truly been a focal issue for trimer-based HIV immunization plan."
Zhu, prepared as a biophysicist, looked for a more broad answer for the Env security issue, and in a paper in 2016 he and his Scripps Research partners announced that adjusting a short, springy segment of Env called HR1 may work - it enabled Env to remain in the pre-contamination, "shut" shape.
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In the new examination he and his group demonstrated that this technique does in reality work for Env trimers from assorted HIV strains flowing in various parts of the world. This "uncleaved prefusion-upgraded" (UFO) approach, as they call it, yields Env trimers that are settled in the shut shape and can be created proficiently, with shockingly little requirement for refinement, in the sorts of cells typically utilized in biotech fabricating.
"At this point in my lab we've made this adjustment to Envs from 30 to 40 diverse HIV strains, and in the greater part of the cases it has had exactly the intended effect," Zhu says.
He and his partners additionally improved their immunization methodology by hereditarily connecting their settled Env trimers, up to 60 at any given moment, to individual nanoparticles that mirror the globular state of an entire infection. Along these lines the antibody particle, however counterfeit and coming up short on the hereditary material for viral replication, appears to the insusceptible framework especially like a genuine attacking infection and animates a more grounded response.
In mice, Zhu and his group found, an example Env-on-nanoparticles immunization, inside only two months, evoked antibodies that in lab tests effectively killed a normally circling HIV strain- - of a sort that earlier hopeful immunizations for the most part have fizzled against.
"This is the first run through any applicant HIV immunization has prompted this coveted sort of immunizer reaction in mice," Zhu says. Essentially remarkable outcomes were acquired in rabbits, exhibiting that the nanoparticle-based methodology is unmistakably better than the utilization of disconnected Env proteins- - it inspires a fundamentally more grounded reaction and does as such considerably more rapidly.
Further tests are presently in progress in 24 monkeys at the National Institutes of Health-supported Southwest National primate Center in San Antonio, Texas.
Zhu and Scripps Research have authorized their HIV immunization innovation to a new business, Ufovax LLC, which is supporting the progressing tests. "We're currently trying two hopeful immunizations dependent on Env trimers from various HIV strains, in addition to a third applicant antibody that is a mixed drink of three Env-based antibodies," says Ji Li, Ufovax CEO. "We think this new methodology speaks to a genuine leap forward following 30 years of HIV immunization investigate."
The add-ons in any make a perfect corporate customer presentation quipping as a long lasting token or keepsake that the recipients will cherish.
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June 05, 2017
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September 02, 2016
Tess went to her bedroom and pulled a glass jelly jar from its hiding place in the closet. She poured all the change out on the floor and counted it carefully. Three times, even. The total had to be absolutely exact. No chance here for mistakes. Carefully placing the coins back in the jar and twisting on the cap, she slipped out the back door and made her way six blocks to the pharmacy with the big red Indian Chief sign above the door.
She waited patiently for the pharmacist to give her some attention but he was too busy at this moment. Tess twisted her feet to make a scuffing noise. Nothing. She cleared her throat with the most disgusting sound she could muster. No good.
Finally she took a quarter from her jar and banged it on the glass counter. That did it! "And what do you want?" the pharmacist asked in an annoyed tone of voice. "I'm talking to my brother from Chicago whom I haven't seen in ages," he said without waiting for a reply to his question.
"Well, I want to talk to you about my brother," Tess answered back in the same annoyed tone. "He's really, really sick… and I want to buy a miracle."
"I beg your pardon?" said the pharmacist .
"His name is Andrew and he has something bad growing inside his head and my Daddy says only a miracle can save him now. So how much does a miracle cost?"
"We don't sell miracles here, little girl. I'm sorry but I can't help you," the pharmacist said, softening a little.
"Listen, I have the money to pay for it. If it isn't enough, I will get the rest. Just tell me how much it costs."
The pharmacist's brother was a well dressed man. He stooped down and asked the little girl, "What kind of a miracle does your brother need?"
"I don't know," Tess replied with her eyes welling up. "I just know he's really sick and Mommy says he needs an operation. But my Daddy can't pay for it, so I want to use my money."
"How much do you have?" asked the man from Chicago. "One dollar and eleven cents," Tess answered barely audibly. "And it's all the money I have, but I can get some more if I need to."
"Well, what a coincidence," smiled the man. "A dollar and eleven cents – the exact price of a miracle for little brothers."
He took her money in one hand and with the other hand he grasped her mitten7 and said "Take me to where you live. I want to see your brother and meet your parents. Let's see if I have the kind of miracle you need ."
That well dressed man was Dr. Carlton Armstrong, a surgeon, specializing in neurosurgery. The operation was completed without charge and it wasn't long until Andrew was home again and doing well.
Mom and Dad were happily talking about the chain of events that had led them to this place. "That surgery," her Mom whispered. "was a real miracle. I wonder how much it would have cost?"
Tess smiled. She knew exactly how much a miracle cost…one dollar and eleven cents…plus the faith of a little child.
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August 11, 2016
These are miserable days when you feel lousy, grumpy, lonely, and utterly exhausted.Days when you feel small and insignificant, when everything seems just out of reach.You can’t rise to the occasion.Just getting started seems impossible.On blue days you can become paranoid that everyone is out to get you .This is not always such a bad thing.You feel frustrated and anxious, which can induce a nail-biting frenzy that can escalate into a triple-chocolate-mud-cake-eating frenzy in a blink of an eye!On blue days you feel like you’re floating in an ocean of sadness.You’re about to burst into tears at any moment and you don’t even know why.Ultimately, you feel like you’re wandering through life without purpose.You’re not sure how much longer you can hang on, and you feel like shouting,"Will someone please shoot me!â€It doesn’t take much to bring on a blue day .You might just wake up not feeling or looking your best,find some new wrinkles, put on a little weight, or get a huge pimple on your nose.You could forget your date’s name or have an embarrassing photograph published.You might get dumped,divorced, or fired, make a fool of yourself in public, be afflicted with a demeaning nickname,or just have a plain old bad-hair day.Maybe work is a pain in the butt.You’re under major pressure to fill someone else’s shoes,your boss is picking on you, and everyone in the office is driving you crazy.You might have a splitting headache,or a slipped dish, bad breath, a toothache,chronic gas, dry lips, or a nasty ingrown toenail.Whatever the reason, you’re convinced that someone up there doesn’t like you .Oh what to do, what to do?
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July 14, 2016
He looked at me and said, "Hey thanks!" There was a big smile on his face. It was one of those smiles that showed real gratitude. I helped him pick up his books, and asked him where he lived. As it turned out, he lived near me, so I asked him why I had never seen him before. He said he had gone to private school before now.
We talked all the way home, and I carried his books. He turned out to be a pretty cool kid. I asked him if he wanted to play football on Saturday with me and my friends. He said yes. The more I got to know Kyle, the more I liked him. And my friends thought the same of him.Monday morning came, and there was Kyle with the huge stack of books again. I stopped him and said, "Dim boy, you are gonna really build some serious muscles with this pile of books everyday!" He just laughed and handed me half the books .
Over the next four years, Kyle and I became best friends. When we were seniors, we began to think about college. Kyle decided on Georgetown, and I was going to Duke. I knew that we would always be friends, that the miles would never be a problem.
Kyle was valedictorian of our class. I teased him all the time about being a nerd. He had to prepare a speech for graduation. I was so glad it wasn't me having to get up there and speak.
Graduation day, I saw Kyle.. He looked great. He was one of those guys that really found themselves during high school. He had more dates than me and all the girls loved him! Boy, sometimes I was jealous.
Today was one of those days. I can see that he was nervous about his speech. So, I smacked him on the back and said, "Hey, big guy, you'll be great!" He looked at me with one of those looks (the really grateful one) and smiled."Thanks," he said. As he started his speech, he cleared his throat, and began. "Graduation is a time to thank those who helped you make it through those tough years. Your parents, your teachers, your siblings, maybe a coach.... but mostly your friends. I am here to tell all of you that being a friend to someone is the best gift you can give him or her. I am going to tell you a story." I just looked at my friend with disbelief as he told the story of the first day we met. He had planned to kill himself over the weekend. He talked of how he had cleaned out his locker so his Mom wouldn't have to do it later and was carrying his stuff home. He looked hard at me and gave me a little smile. "Thankfully, I was saved. My friend saved me from doing the unspeakable."
I heard the gasp go through the crowd as this handsome, popular boy told us all about his weakest moment. I saw his Mom and Dad looking at me and smiling that same grateful smile. Not until that moment did I realize it's depth .
Never underestimate the power of your actions. With one small gesture you can change a person's life. For better or for worse.
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May 06, 2016
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April 20, 2016
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